INS and obesity due to melanocortin 4 receptor deficiency: In this context, it might entail special relevance to analyze the effect of miR6262 on hepatocyte gluconeogenesis, based on (1) the remarkable downregulation of G6PC mRNA promoted by miR6262 reported in the present study, and (2) the fact that liver gluconeogenesis could be suppressed by targeting G6PC which improves liver and adipose tissue metabolic profile, insulin sensitivity and diet-induced obesity [74,75].