In the in vitro model of liver steatosis (HepG2 cells exposed to FFA), the plant miRNA-human target gene bioinformatic prediction was validated, reporting a marked downregulation of the putative target RXRA (−38.05% ± 3.91; p < 0.001) as compared to control cells (Figure 1a). Here, RXRA is linked to Hepatic steatosis.