SFRP5 and obesity due to melanocortin 4 receptor deficiency: An individualized lifestyle intervention program consisting of a healthy diet, good quality sleep, and physical exercise for 1 year resulted in a significant increase in Sfrp5 concentrations in children and adolescents with severe obesity, along with a significant amelioration in parameters of metabolic syndrome, such as body composition and clinical indices of obesity, hepatic enzymes, markers of inflammation, indices of insulin resistance, and profile of lipids.