In another study, obesity-related post-traumatic osteoarthritis mice had 14 weeks of a diet that was abundant in n-3 PUFAs, and the diet alleviated the osteoarthritis-like lesions of articular cartilage and osteoarthritis progression, along with the reduction of proteins of high-mobility group box 1 (HMGB1), the receptor for advanced glycation end products (RAGE), and toll-like receptor 4 (TLR4) [130]. Here, AGER is linked to obesity due to melanocortin 4 receptor deficiency.