However, close monitoring of outcomes related to nutritional status and/or mineral bone metabolism, such as body composition assessment, hand grip strength, total protein/albumin, prealbumin, N-terminal procollagen peptide levels, type I collagen cross-linked C-telopeptide, calcium, phosphates, PTH, calcitriol, calcitonin, creatinine, GFR, proteinuria, and metabolic acidosis, among others, is crucial to improve the continuous adjustment and effectiveness of LPDs and VLPDs. The gene discussed is TTR; the disease is metabolic acidosis.