TNF and metabolic dysfunction-associated steatotic liver disease: Following the identification of the compound, targets are typically predicted using databases such as Swiss Target Prediction or Search Tool for Interacting Chemicals (STITCH), focusing on proteins known to be involved in MASLD pathogenesis, such as AKT serine/threonine kinase 1 (AKT1), interleukin-6 (IL6), vascular endothelial growth factor A (VEGFA), tumor necrosis factor (TNF), and peroxisome proliferator-activated receptor gamma (PPARG).