Genetic studies in mice and primary hepatocytes show that lncRNA regulator of hyperlipidemia (lncRHL) activates the lncRHL/heterogeneous nuclear ribonucleoprotein U (hnRNPU)/brain and muscle aryl hydrocarbon receptor nuclear translocator (ARNT)-like protein 1 (BMAL1)/microsomal triglyceride transfer protein (MTTP) axis, revealing new molecular mechanisms of lipid homeostasis in the liver and blood circulation [117]. The gene discussed is HNRNPU; the disease is hyperlipidemia.