SOD1 and liver dysplastic nodule: Our group recently showed that administration of vitamin B12 (B12) either alone or in combination with other compounds [alpha lipoic acid (ALA), superoxide dismutase (SOD), acetylcarnitine (ALC)] results in a significant clinical improvement in functional aspects (indices) of DN, but only to a moderate and probably slightly clinically significant reduction of neuropathic pain [5,6].