We designed and conducted the present study to extend the understanding and the clinical utility of the findings of two recent studies of our group, in which we showed that administration of vitamin B12, either alone or in combination with other compounds (ALA, SOD, and ALC), leads to a significant improvement in functional aspects (indices) of DN, but to only a moderate improvement in the diabetic neuropathic pain score [5,6]. The gene discussed is ALLC; the disease is liver dysplastic nodule.