Similarly, Karlovic and colleagues (2007) found that LiCl treatments (20 mmol/L) in A1235 glioblastoma cells altered the levels of proteins such as Bcl-2 and proCAS-3, and there was no cleavage of PARP1 [40], reinforcing with our work that lithium does not affect this pathway. This evidence concerns the gene BCL2 and glioblastoma.