The results of KEGG enrichment analysis showed that 317 signaling pathways for 288 target genes were obtained (p < 0.05, Table S5), and the top 30 enriched pathways are shown in Figure 7E. The results showed that the targets of ZDS in the treatment of RA were mainly enriched in pathways in cancer (n = 78), the MAPK signaling pathway (n = 55), the PI3K-Akt signaling pathway (n = 51), lipid and atherosclerosis (n = 46), Kaposi sarcoma-associated herpesvirus infection (n = 41), and so on, which could be the key pathways in the effect of ZDS against RA. Here, AKT1 is linked to atherosclerosis.