Compounds 1, 5, and 7 could significantly reduce the level of IL-1β, IL-6, and TNF-α in LPS-induced HFLS-RA cells, while compound 7 has a significantly higher inhibitory effect on IL-6 than compounds 1 and 5 at the test concentration, and this is consistent with the results of molecular docking verification. This evidence concerns the gene IL1B and rheumatoid arthritis.