In this regard, DIM has been shown to suppress the expression of HDAC2 and HDAC3 proteins in mouse prostate cancer TRAMP-C1 cells, with a concomitant increase in apoptosis, a decrease in cell proliferation, and enhanced Nrf2 and Nrf2 target gene NQO1 expression [99]. The gene discussed is NFE2L2; the disease is prostate carcinoma.