BBC3 and colorectal cancer: The binding of LL-37 to one of the G-protein-coupled receptors, although not yet fully characterized, results in decreased Bcl-2 levels and induces a cascade of apoptotic proteins, including Bax, Bak, Puma, and p53, as well as endonuclease G (EndoG) in HCT116 colorectal cancer cells [38].