These results corroborate the in vitro findings on the synergistic role of NTS1R and GRPR on tumor targeting and manifest clear advantages of employing the [99mTc]Tc-DB7+[99mTc]Tc-DT11 cocktail vs. single [99mTc]Tc-DB7 or [99mTc]Tc-DT11 in this prostate cancer model. Here, GRPR is linked to neoplasm.