CD274 and neoplasm: Chouljenko et al. generated an oncolytic HSV-1 strain encoding IL-12 and -15, the alpha subunit of the IL-15 receptor, as well as an anti-PD-L1 blocking peptide, and found that it elicited robust anti-tumor effects when administered IT to treat subcutaneous CT26 and A20 B cell lymphoma tumors in syngeneic mice.