It is worth acknowledging that PD-1/PD-L1 ICI-induced irAEs in children have not been well-characterized relative to adults due to the rarity of pediatric cancers, as well as the poor immunogenicity and lack of PD-L1 expression in many pediatric cancers, making PD-1/PD-L1 ICIs less effective in this patient population. Here, CD274 is linked to cancer.