EIF4E and breast cancer: An overexpression or hyperactivation of factor eIF4E has been implicated in the translation of mRNA targets including cyclin D1, c-Myc, VEGF, and Bcl-2, which are known to depend on ER signaling and contribute to BC progression, and also the increase in translation of pro-survival proteins, including those involved in drug resistance mechanisms such as anti-apoptosis and drug efflux pumps.