Rashed et al. proposed a new integration of gene therapy and nanocarriers as a promising tool in therapies for hepatocellular carcinoma; they proposed the formulation of zein nanoparticles as a new delivery system for PTEN (phosphatase and tensin homolog deleted from chromosome ten) and TRAIL (TNF-related apoptosis-inducing ligand) genes, which are two oncosuppressors. Here, TNFSF10 is linked to hepatocellular carcinoma.