The medulloblastoma with a high Shh level can be also targeted by biomimetic high-density lipoprotein (HDL) NPs that bind to the HDL receptor (scavenger receptor type B-1, SCARB1), resulting in the depletion of cholesterol levels in cancer cells and thus effectively blocking the proliferation of medulloblastoma cells and colony formation [95]. This evidence concerns the gene SHH and medulloblastoma.