TGFB1 and triple-negative breast carcinoma: Small interfering RNA (siRNA) to integrin β3 via lipid ECO-based NPs (ECO/siβ3) can effectively silence integrin β3 expression, restore TGF-β-mediated cytostasis, decrease TGF-β-mediated epithelial–mesenchymal transition (EMT) and invasion, and suppress three-dimensional organoid growth in triple-negative breast cancer (TNBC) [50].