HES1 and colorectal cancer: Mang-PLGA-NPs inhibited colorectal cancer cell viability, colony formation, and EMT, enhanced programmed cell death, and inhibited the cancer stem-like cell population by suppressing Notch signaling components (such as Notch-1, Notch-2, DLL4, and Jagged 1), Hes-1, and γ-secretase complex protein, indicating that Mang-PLGA-NPs could be used to treat and prevent colorectal cancer [91].