The treatment of the chemotherapeutic drug cisplatin inhibiting DNA replication with anti-human epidermal growth factor receptor 2 (HER2) antibody-conjugated and autophagy inhibitory microRNA (MIR376B)-loaded superparamagnetic iron oxide NPs enhanced anticancer treatment efficiency in both xenograft nude mice with breast cancer and HER2-positive breast cancer cells [64]. This evidence concerns the gene ERBB2 and breast carcinoma.