JAK2 and cancer: Another natural compound studied is 2-deoxy-4β-propylcarbamate-pulchelin (44) (Figure 27), a sesquiterpene lactone derived from 2-deoxy-4-epi-pulchelin from the medicinal herb Carpesium abrotanoides L. Huang et al. [86] showed that compound 44 inhibits the growth of a panel of human cancer cell lines (A375, A2058, DU145, H4, BEL7404, LM3, MDA-MB-453, MDA-MB-231, HT29, HCT116, HT1650, and H460) with IC50 values ranging from 3.0 to 21.0 μM and also inhibited JAK2 kinase activity.