In the study by Lu et al. [129], cationic self-assembled N-[1-(2,3-dioleoyloxy) propyl]-N, N, N-trimethylammonium methyl sulfate (DOTAP) and monomethoxy poly(ethylene glycol)-poly(ε-caprolactone) (MPEG-PCL) hybrid micelles (DMP) were produced to transport Bcl-xl siRNA and Mcl1 siRNA for colon cancer treatment. The gene discussed is MCL1; the disease is malignant colon neoplasm.