From T0 to T1 there was a significant increase in opioid analgesics, antipsychotics, locally acting corticosteroids, prokinetics and antiemetics and antispasmodics and a significant decrease in drugs for the treatment of peptic ulcers and GERD, antithrombotics, lipid-lowering agents, antihypertensives, antidiabetics (excluding insulins) and vitamin and mineral supplements. This evidence concerns the gene INS and Peptic ulcer.