Hippocampal function-related genes (BDNF, PSD-95, Synaptophysin, Cholecystokinin, Calbindin 1, Syntaxin 1a, NeuroD6, and NeuroD2) were significantly downregulated in the hippocampus of PTSD mice, although they were restored by HFE treatment. This evidence concerns the gene NEUROD2 and post-traumatic stress disorder.