SLC6A4 and major depressive disorder: Paroxetine (Seroxat) binds to the receptors SERT, D2, 5-HT1, 5-HT2, 5-HT3, H1, α1, α2, and β, reflecting its strong action on serotonin reuptake and has a significant impact on various serotonin receptor subtypes, which may explain its efficacy in treating anxiety disorders and depression.