CD4 and AIDS: However, other factors can additionally cause early menopause, such as low BMI, ethnicity, smoking, low CD4+ cell count, hepatitis C virus coinfection, and a history of Acquired Immunodeficiency Syndrome (AIDS) [20,72] The mechanism of this correlation is multivariant, as one of the most prevalent predictors of early onset of menopause is the use of tobacco inhalation inhalation [51].