Reduces viral shedding and recurrent disease in ocular and vaginal herpes, TG, and brain neurons. gB induces expression and release of IFN-γ, granzyme B, and CD107a and decreases T-cell exhaustion (LAG-3, PD-1, and TIM-3). Protects against severe infections and lethal IV antigen challenge. This evidence concerns the gene GZMB and infection.