In the quest for effective AD treatment, scholars from various countries have actively explored the pathogenesis of AD and proposed various hypotheses, such as neurotoxicity caused by Aβ deposition, abnormal phosphorylation of Tau protein, the cholinergic hypothesis, oxygenation stress response, and the cell apoptosis theory [6,7,8,9]. The gene discussed is MAPT; the disease is Alzheimer disease.