It decreases the production of aqueous humor and increases uveoscleral outflow, meaning it is commonly used to manage glaucoma due to these hypotensive properties. Alpha2-adrenoceptors have been found in the retinal ganglion layer and inner nuclear layer, indicating potential neuroprotective advantages. They can upregulate retinal expression of anti-apoptotic proteins, including bcl-2 and bcl-x, thereby protecting the RGCs. The gene discussed is BCL2; the disease is glaucoma.