In placenta extract studies, porcine placenta extract was found to be beneficial in the prevention and treatment of osteoporosis through regulation of ERK 1/2 and Akt in human osteoblast hFOB 1.19 cells [59], and the role of porcine placenta extract established in influencing the correlation between ceramide synthase 3 and Akt in HaCaT cells was defined, but this study is the first to report on the relationship between human placenta and Akt [60]. The gene discussed is CERS3; the disease is osteoporosis.