CASP3 and hepatocellular carcinoma: Moreover, qRT-PCR results showed that wogonin and glycitein could significantly reduce the expression levels of EGFR and STAT3, down-regulate Bcl-2, and up-regulate the gene levels of Bax, Caspase-3, Caspase-8, and Caspase-9 in HCC cells, which were involved in inducing apoptosis of HCC cells (Figure 8D).