AKT1 and Hypertension: Meanwhile, 14 main targets of action were also predicted for treating hypertension, which may be related to the HIF-1 signaling pathway, the calcium signaling pathway, the vascular endothelial growth factor (VEGF) signaling pathway, the phosphatidylinositol 3-kinase-protein kinase B (Akt) signaling pathway, the cyclic guanosine monophosphate-protein kinase G signaling pathway, and the estrogen pathway, respectively [107].