Chia seeds struggle with NNK-induced lung carcinoma in rats through (i) inhibition of c-MYC and MMP9 gene expression, (ii) decreased proliferation, (iii) increase in apoptosis, (iv) reduction in angiogenesis, (v) suppression of IL-6 and IL-1β levels, and (vi) increase in non-enzymatic (GSH content) and activation enzymatic (GR, GST, and GPx) activities. The gene discussed is GSR; the disease is lung carcinoma.