The excellent ratios of infiltrating CD8+/CD4+ T cells, decreased invasion of regulatory forkhead box P3 (FOXP3)+ Treg lymphocytes, increased apoptosis caused by cysteine-aspartic protease (Caspase) 9/Caspase 3 overexpression, and baculoviral inhibitor of apoptosis repeat-containing 5 (Survivin) downregulation suggest that H. pylori pIRES2-DsRed-Express-ureF DNA vaccines may have immunotherapeutic utility in individuals with advanced GC [53]. The gene discussed is CD4; the disease is gastric cancer.