CD8A and cancer: Le, by testing the effect of Taraxaci herba flavone (TF) on cancer cells in the Lewis mouse lung cancer model, it was found that under the influence of 200 μg/mL TF, the levels of CD4+, CD8+ and CD4+/CD8+ in cancer cells increased, the levels of IL-2, IL-3, IFN-γ, and TNF-α increased, and the expression of Ki67 decreased significantly, thus inhibiting the proliferation of lung cancer cells and improving the host’s immunity [133].