F10 and stroke disorder: These include ARISTOTLE (Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation), ROCKET-AF (Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation), RE-LY (The Randomized Evaluation of Long-Term Anticoagulation Therapy), and ENGAGE AF (Effective Anticoagulation with Factor Xa Next Generation in Atrial Fibrillation).