Based on the revised articles, it can be concluded that although there are reports on the prevalence of mutations in the BRCA1 and BRCA2 genes in South American countries, such as Chile, Colombia, Argentina, Uruguay, and Brazil, including Mexico as Hispanic, the general prevalence is close to 15–20% in women with hereditary risk factors or those diagnosed with ovarian and/or breast cancer. This evidence concerns the gene BRCA2 and breast cancer.