Validation analysis confirmed that ten pathway expressions, including wound-healing signaling, glucocorticoid receptor signaling, macrophage alternative activation signaling, IL-33 signaling, S100 family signaling, MIF-mediated glucocorticoid regulation, serotonin receptor signaling, MIF regulation of innate immunity, VEGF family ligand–receptor interactions and tumor microenvironment, showed significant differences among lesional, non-lesional and healthy skin. This evidence concerns the gene IL33 and neoplasm.