Genes implicated in wound healing (CXCL8, HBEGF, IL36A, IL36G, KRT16, KRT17, KRT6A, KRT6B, KRT6C, MMP1 and PGF), genes implicated in glucocorticoid receptor signaling (CCL2, CXCL8, IL4R, KRT16, KRT17, KRT6A, KRT6B, KRT6C, MMP1, PLA2G2F, PLA2G and SELE) and genes implicated in S100 family signaling (CCL20, CCR7, CXCL8, MMP1, MMP12, S100A12, and S100A8) and other pathways showed a higher pathway expression pattern in lesional AD compared to healthy skin and non-lesional AD skin (Figure 3A–D and Figure S6). Here, CCL2 is linked to Alzheimer disease.