The 240 DECGs in the blue module derived from lesional and non-lesional AD are enriched in 51 pathways, with the 5 most significant pathways included atherosclerosis signaling, interferon signaling, S100 family signaling, IL-17 signaling, and differential regulation of cytokine production in intestinal epithelial cells by IL-17A and IL-17F (Table S5). The gene discussed is IL17F; the disease is Alzheimer disease.