These include up-regulated genes such as SERPINB4, S100A9, S100A8, SPRR2A, S100A7, S100A7A, SPRR2B, KRT16, HEPHL1, and DEFB4A, as well as down-regulated genes such as KRT77, BTC, WIF1, FABP7, CHRM4, ALOX15, SOCS3, NELL2, TMPRSS4, and MMP12), which may enhance our understanding of the AD disease mechanisms and contribute to personalized medicine. This evidence concerns the gene SPRR2A and Alzheimer disease.