S100A8 and Alzheimer disease: These include up-regulated genes such as SERPINB4, S100A9, S100A8, SPRR2A, S100A7, S100A7A, SPRR2B, KRT16, HEPHL1, and DEFB4A, as well as down-regulated genes such as KRT77, BTC, WIF1, FABP7, CHRM4, ALOX15, SOCS3, NELL2, TMPRSS4, and MMP12), which may enhance our understanding of the AD disease mechanisms and contribute to personalized medicine.