Moreover, differential regulation of cytokine production in intestinal epithelial cells by the IL-17A and IL-17F and IL-13 signaling- associated gene DEFB4A had high diagnostic performance in the GSE121212 (AUC = 0.775) and GSE107361 (AUC = 0.808) datasets, followed by OAS2 in the GSE121212 (AUC = 0.76) and GSE107361 (AUC = 0.588) and MMP1 in the GSE121212 (AUC = 0.729) and GSE107361 (AUC = 0.875) datasets in classifying non-lesional AD from healthy skin. This evidence concerns the gene MMP1 and Alzheimer disease.