Bacterial endotoxins as lipopolysaccharides (LPS) and pro-inflammatory products such as C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-alpha), and interleukin-1 and -6 (IL-1, -6) resulting from periodontal disease have been suggested to increase the risk of nervous system inflammation entering via the oral cavity [17]. Here, TNF is linked to periodontal disorder.