In summary, the significant co-occurring pairs of genes observed in our NB cohort included APOB and PREX2, RNF213 and LRRN3, CNTRL and ITGAV, and LAMA5 and LRRN3, whereas somatic interactions, in terms of mutually exclusive events, were observed for MUC4 and SETD2. This evidence concerns the gene RNF213 and neuroblastoma.