Women who present with a history of both provoked and unprovoked VTE or with first-degree relatives diagnosed with inherited thrombophilia should be evaluated with a thrombophilia panel, including tests for antiphospholipid syndrome, factor V Leiden, and the prothrombin G20210A gene variant, as well as for deficiencies in antithrombin III, protein C, and protein S [15]. The gene discussed is PROS1; the disease is Rare hereditary thrombophilia.