Pregnancy and the postpartum period are also associated with a hypercoagulable state, with a physiologic increase in certain coagulation factors, such as factors II, VII, VIII, IX, and X. Conversely, there is also a reduction in the production of protein S and a decrease in the activation of the fibrinolysis inhibitors PAI-I and PAI-2 [13]. The gene discussed is PROS1; the disease is thrombophilia.