CDK4 and metastatic neoplasm: OS in our study since the diagnosis of metastatic disease was 4.5 years (95% CI 3.9–6.3), median OS since the start of CDK4/6 treatment was 3.7 years (95% CI 3.4–4.4), while median OS from initial cancer diagnosis was 15.8 years (95% CI 13.8–18.3).