In our study, we observed elevated levels of eosinophiles in the blood of CRSwNP patients compared to NC patients, as well as a positive correlation between blood eosinophile counts and tissue CNPase levels in both CRSwNP and CRSsNP patients, and with TGFβ1 in CRSwNP patients. Here, CNP is linked to chronic rhinosinusitis with nasal polyps.