GPT and Heat Stroke: In their study, “2 out of 3 of the following must have been met to be considered heat injury or heat stroke: aspartate transaminase/alanine transaminase fold increase >3, creatine kinase fold increase >5, and/or creatinine ≥ 1.5 mg/dL.” Based on this definition, there were 80 cases that met their diagnostic criteria, but of those, only 28 were diagnosed as such, providing a limited Sn of 65%.