CDKN2A and melanoma: High-risk groups for developing melanoma include individuals with genetic predisposition (CDKN2A mutation), those with skin that tends to burn (phototype I and II), people with inherited melanocortin-1 receptor (MC1R) variants, individuals with a high number of common nevi, those with large congenital nevi, multiple and/or atypical nevi, personal melanoma history, and individuals with intermittent high sun exposure [5].