HLA-C and infection: While the KIR ligand group for single HLA-C alleles is not correlated with SOFA scores (Figure 7C, p> 0.98), a significant dose-dependent correlation exists between patient HLA-C1/C2 genotype and SOFA score, where increasing C1 allotypes in a given patient are associated with more severe infections (ANOVA p< 0.04, Figure 7D).