F2R and coronary artery disorder: Specifically, Duffy et al. demonstrated that, among patients with coronary artery disease (CAD), the consumption of black tea, despite the presence of antioxidant flavonoids known to decrease platelet aggregation in vitro, did not lead to altered dose-dependent platelet aggregation in response to Adenosine diphosphate (ADP) and thrombin receptor-activating peptide either acutely or chronically [58].