Therefore, in our study, we have chosen the molecules of the RANK/RANKL/OPG axis and the Wnt/DKK1/sclerostin pathway, because these molecules play a key role in controlling the relationship between bone homeostasis, the immune system and inflammation on the RA disease spectrum and other osteoimmune diseases [19,20]. The gene discussed is TNFRSF11A; the disease is rheumatoid arthritis.