Lempinen et al. found that an AUC of 0.745 at 24 h after admission for serum levels of trypsinogen-2 could differentiate between a mild and severe course of AP, performing similarly to trypsinogen-1 (AUC of 0.768) but significantly poorer than urinary levels of trypsinogen-2, with an AUC of 0.925 [24]. Here, PRSS2 is linked to alkaline phosphatase measurement.