APOE and Alzheimer disease: In patients with AD, an interaction model was observed, including three polymorphisms present in the MAPT gene rs242557 (A allele), rs2471738 (T allele), and rs3785883 (A allele) with the APOE ε4 allele (p < 0.001; OR = 5.221 95%CI (2.697–10.108)) (Table 4).