The activation of the VEGF-A/VEGFR2 signaling pathway is implicated in excessive angiogenesis in DKD, with downstream pathways including phospholipase C (PLC)-γ/protein kinase C (PKC), PI3K, and p38-MAPK, promoting endothelial cell proliferation, migration, survival, and increased vascular permeability [20]. This evidence concerns the gene VEGFA and diabetic kidney disease.