The proteomics analysis of the EVs using Metascape revealed enrichment in the critical biological pathways, including RNA metabolism, organelle organization, proteolysis regulation, and vesicle-mediated transport, alongside those pathways directly relevant to cancer progression, such as RHO GTPase signaling, VEGFA-VEGFR2 signaling, and cell cycle regulation (Figure 4C). This evidence concerns the gene RHO and cancer.