Consequently, it could be proposed (hypothetically) that zinc deficiency is predisposed to the expression of genes involved in the synthesis of Tg and TPO, inducing these thyroid autoantigens to have a configuration that confers greater “antigenicity” and, eventually, a greater probability of triggering an autoantibody-mediated response (TgAb and TPOAb). The gene discussed is TPO; the disease is Zinc deficiency.