NFE2L2 and osteochondritis dissecans: However, TGN significantly diminished VTX’s protective effects, suggesting that VTX’s neuroprotective benefits against HPD-induced OD are likely due to its ability to neutralize excess NO and free radicals, improve antioxidant defenses, sustain mitochondrial function, and inhibit inflammation and apoptotic pathways in the striatum, potentially through interactions with the Nrf2-mediated pathway.