The CXCR5+ cTfh, cTfr, and non-cTfh/cTfr cells were present in both HC and RA patients’ samples, and all circulating CD4+CXCR5+ T-cell subsets have shown a significantly higher frequency in RA compared to HCs (Figure 1d). The gene discussed is CXCR5; the disease is rheumatoid arthritis.